Friday, April 21, 2017

Requiems




I have listened to both Berlioz's and Mozart's Requiem this morning.

I need to get outside this afternoon but my heel has betrayed me, again. My doctor seems to suspect plantar fasciitis, though I am convinced the gods have come down from the hills to give me the clap, or worse: the gout. I have prayed for death all morning with the greatest submission to the skies that I can muster. All that is left now will be Faure's version, at sundown.  

I can't walk. I crawled from my bedroom to the kitchen in the middle of the night to get to my computer and then to self-diagnose on WebMD, gobbling Alleve as if it was Midol and my ankle embroiled in its own purgationibus mulierum. 

A Midsummer Night's Midstream. 

I have considered the impact of amputation, as well as its application. It would perhaps involve an excessive amount of recovery time, and friends with very strong ideals.

I searched my memory for what might have caused the gout and nothing made any sense. I have now come to accept my doctor's assessment and am quite relieved at having done so, even though there will need to be tests to verify that there is no urine surging through my veins.

At least with the fasciitis I can blame the republicans and not my own diet. My gods, you don't know the torture in going through my daily diet from yesterday trying to find the culprit. It was as if someone was about to steal something very valuable from my cup boards and refrigerator and I had to discover who it was going to be. My only hope was to find that some food I loved daily has betrayed me. Before lunchtime arrived I was sunken into a Sophie's Choice of sorts, having narrowed the possible perpetrators down to only two.

By the time of writing this I have grown certain that any one of my vegetariable ex-girlfiends cast this heel hex on me for being an omnivore. As I reclined in bed with my leg elevated I read up on gout. It is a genuine malady, reserved for reprobates and chronic imbibers. I felt destined that it had come for me, the prodigal malady.

You're supposed to fall out of love with yourself to treat it effectively - no scallops, beef, or lamb; no pork, even bacon. The article's recommendations then attacked beer and gravy in a serial manner, listing off so many of the keys to the kingdom. A merciless crippler of culinary intake, that.


Beware:





According to the theory of evolution, why do we die?


Excellent question. And before I explain the real answer, which is rather mind-bending, here are some previous arguments and why they are wrong.

Myth 1: We die to make room for younger generations.
Genes are selfish, and each individual body is a vehicle for a collection of genes. These genes are selected to favor the survival of copies of themselves. Since parents and offspring use the same resources, the death of a parent creates room ecologically for just one offspring. Each gene in the parent has a 50% chance of appearing in this offspring. But it has a 100% chance of appearing in the parent, because it's already there. It's never, then, in the evolutionary interests of a parent to die so an offspring can replace it.

Myth 2: We die because our cells/DNA get damaged with age.
This like saying bad drivers die because of blood loss. It's a proximate mechanism of death, not the evolutionary cause of mortality.

Our somatic cells (the cells that are part of our body) do indeed suffer occasional mutations as they divide. These mutations can kill or damage cells, which is annoying but not generally a big problem as we can make more. However, the worst mutations do something much more dangerous: they help cells to survive and proliferate. That's how you get cancer. Because this risk accumulates over time, cells are normally allowed only a limited number of divisions before they undergo cellular senescence, that is, they die. But the genes that cause cellular senescence can also stop working. So that's one of the ways in which we get old: our somatic cell lineages get older, damaged and mutated, and some become cancerous.

However, the cell/DNA damage idea assumes that this isn't something evolution can counteract. And that's clearly false. Lifespan and cancer rates differ between species, and not in the ways you would expect if they were determined by cell/DNA damage. For instance, once you take into account body size and phylogeny, DNA repair doesn't correlate with lifespan. Lifespan does, however, correlate with ecology: mammal species who typically lead risky lives die younger (even if you protect them from those risks). At one extreme, in the harsh Australian bush we find the male agile antechinus, who dies of stress at the end of a single breeding season. At the other extreme, the naked mole rat can live for three decades in its peaceful underground colonies.

This gets even more puzzling when you start to look at genomics. We have a whole suite of genes devoted to keeping our genome pristine. My favorite is a clever gene called P53 that acts as a "gatekeeper" for cell division. If the cell has too many mutations, P53 will halt division and activate repair mechanisms. If that doesn't fix things, it will make the cell commit suicide. Mutations that break P53 are involved in about half of all human cancers. Now, here's the rub: there's a whole family of genes related to P53 in other mammals, and some work better than others. Naked mole rats, as it happens, have two particularly awesome versions that completely protect them against cancer.

We also know that it's perfectly feasible for genetic modification to immortalize cell lineages, and that going through a haploid stage is not essential for maintaining cell viability. How do we know this? From the strange case of the 11,000 year old dog. The dog as an individual is long dead, but her cells survive today as an infectious cancer on other dogs' genitalia. There's also a quaking aspen in Utah whose roots are at least 80,000 years old.

The same applies to permanent organ damage. Some organs heal and regenerate, some don't. Some species can regenerate organs that others can't. A salamander can grow a whole new leg. There's even a jellyfish that can reverse its development when it's damaged. All in all, natural selection is clearly capable of creating creatures who can fix cellular and DNA damage and repair damaged organs.

So: evolution can fix these problems for us, and it doesn't. What the heck, evolution, aren't we friends?

Well, no, actually, evolution is not our friend. If anything, it's our genes' friend. And there's a very good reason our genes don't actually care about us.

Mutations are a problem evolution can fix. But death isn't. Accidents happen. Diseases happen. Sabre-toothed cats happen (well, not any more, but you get the point). No matter how hard our genes try to help us survive, sometimes they're going to fail. These failures are often, as far as your genes are concerned, random. And that means our genes can't afford to get too invested in the survival of any individual. In the long term, the only way a gene can survive is to spread -- to copy itself through a population.

So from a gene's-eye view, every investment in your survival is a potential trade-off with the creation and survival of your potential descendants. And, rather obviously, the more likely you are to die randomly, the less it makes sense for your genes to invest in the survival side of the equation.

Every day of your life, the Universe in effect rolls a pair of many-sided dice. Snake eyes, you're dead. Every day the probability that the Universe has at some point in the past killed you increases. And at some time after your birth, on average, you're dead.

Look at this from your genes' perspective. Your genes don't know about you specifically, their behavior is selected based on statistics. They don't want to invest in somebody who is, on average, dead. Younger people are, on average, more likely to be alive. So if your genes have to choose between investing in (on average) the survival and/or reproduction of young you versus old you, they'll pick young you.

And quite often they do have to choose. Early in development, for instance, you really need genes that allow lots of cellular proliferation. Your body can't grow without it. But too much cellular proliferation when you're fully-grown is a big problem. So it's a delicate balance, and what's good for you when you're a kid can be bad for you when you're grown up. There are other genes that manage these risks by switching genes on and off throughout your life, but that makes the network even more complex and failure-prone. You end up with an intricate genomic dance going on throughout your whole life. So it's hardly surprising that some genes end up helping you now and harming you later.

One example may be Huntington's Disease, a horrible dominant genetic disorder that slowly destroys your brain and kills you. The disease usually starts to affect people in middle age. However, young people with the Huntington's gene have more children on average. It's thought that the Huntington's gene strengthens the immune system by increasing activity of P53, making them healthier and more fertile. Other possible examples include atherosclerosis, sarcopenia, prostate hypertrophy, osteoporosis, carcinoma and Alzheimer's disease.

As life goes on, your genes effectively stop caring what happens to you. After a certain point, it's so unlikely that you're still alive that your genes can safely assume you'll already be dead. So your genomic programming can contain all sorts of wacky stuff that only kicks in after this point, just because there's no noticeable selection against it.

The really fascinating part (by which I mean the really depressing part) is how this effect reinforces itself. The more likely it is that you're dead, the less your genes care about you. The less your genes care about you, the more likely it is that you're dead. And this has been going on throughout our evolutionary history, so we've accumulated all sorts of weird malfunctions that kick in late in our lives. The human genome is riddled with them, and most of the genes involved are also part of normal development and reproduction. These malfunctions cluster around a certain age: the age when evolution stops caring about us because, statistically speaking, we're already dead.

So mortality is an evolutionary prophecy that fulfills itself in a multitude of ways. And that's why there's no single key to eternal life. Poor old Gilgamesh.


Suzanne Sadedin, Ph.D. in evolutionary biology from Monash University



.

No comments:

Post a Comment